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Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis

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Among 2-OGDDs, Jumonji C domain-containing histone demethylases and ten-eleven translocation (TET) family DNA demethylases are major enzymes that induce epigenetic modifications using glutamine-derived -KG

FOXO4-p53 Disruption Moderate Research Detailed mechanistic studies confirm that FOXO4-DRI achieves its senolytic effects through precise disruption of the protective FOXO4-p53 protein interaction that allows senescent cells to evade apoptosis and persist in tissues